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Conflicting Biomedical Assumptions for Mathematical Modeling: The Case of Cancer Metastasis

Figure 5

Agreement across experts by discussion topics.

We grouped the comments of experts into several topics. Within each topic (represented here by a row), an expert may have mentioned several ideas he or she agrees with, disagrees with, or is unsure about. This heat map depicts the main topics for modeling the process and how many ideas under each topic every expert (columns: 1–28) discussed, along with their agreement. An asterisk (*) indicates a topic whose frequency of mention was statistically significant compared to the null model of a uniform distribution of comments (see Table S1). Abbreviations: Def = Definition, Dev = Development, Env = Environment, Evol = Evolution, Met = Metastasis, Mic = Micro, Trop = Tropism.

Figure 5

doi: https://doi.org/10.1371/journal.pcbi.1002132.g005