Cadherin-Dependent Cell Morphology in an Epithelium: Constructing a Quantitative Dynamical Model
Figure 9
Analysis of P cell misexpression simulations.
(A) Total error Fe for different simulations as a function of N+/N0. The red line describes the simulation error when P cells express N-cadherin before cone cells, and P cells do not contact each other until after the onset of N-cadherin expression in cone cells. The purple line describes simulation error when P cells express N-cadherin before cone cells but P cells are always in contact with each other. The black line describes simulation error when P cells and cone cells simultaneously begin N-cadherin expression, and P cells always are in contact with each other. (B) Error contributions to the best-fit model are dominated by the same fe terms as in the other misexpression simulation, except that the symmetric structure of this mutant has no Dx contribution to the error. The minimum is located at N+/N0≈1.2. (C) The effect of N+/N0 on the shape of the ommatidium, with only values near the error function minimum approximating the observed cruciform mutant shape. (D) Binding strengths of N-cadherin on various edges of the structure as N+/N0 varies. Note the absence of binding on PP edges for N+/N0<1.2.