Mutual Inactivation of Notch Receptors and Ligands Facilitates Developmental Patterning
(A) Schematic of a simplified lateral inhibition circuit architecture. Here, Notch signaling activates expression of the Notch gene. Notch activation thus leads to higher Notch levels which, in turn, lead to lower levels of free DSL due to the mutual inactivation interaction between Notch and DSL proteins in cis (dashed arrows). (B) Calculation of the MLE for the SLIMI model. The SLIMI model can support patterning without cooperative feedback over a large region of parameter space. Color scale is the same as in Fig. 5A–D. Equations and parameters are described in the Supporting Information Text S1.3 and Table S1, respectively.