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Mutual Inactivation of Notch Receptors and Ligands Facilitates Developmental Patterning

Figure 5

Mutual inactivation circumvents requirement for cooperative feedback.

Escape rates from the HSS (indicated by Maximum Lyapunov Exponents, or MLE) as a function of and . MLE values were calculated using linear stability analysis (Supporting Information Text S1.4) for the LI (A,C) and LIMI (B,D) models. Positive MLE values (white/pink regions) support patterning, while negative MLE values (blue regions) do not. The dependence on feedback loop cooperativity (inset) can be seen by comparing (A,B) to (C,D). Black dots in A and B correspond to the parameters used to simulate Fig. 4DE.

Figure 5