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Mutual Inactivation of Notch Receptors and Ligands Facilitates Developmental Patterning

Figure 1

Ultrasensitivity due to mutual inactivation of Notch and DSL.

(A) Plot of free DSL (red) and free Notch (blue) as a function of DSL production rate, . A sharp switch (high logarithmic derivative) between sender and receiver states occurs when . (B) Schematic illustration of sending and receiving states, showing that while very little signaling occurs when two neighboring cells are both senders (top) or both receivers (middle), strongly biased signaling can occur for the case of neighboring sender and receiver cells (bottom).

Figure 1