Brownian Dynamics Simulation of Nucleocytoplasmic Transport: A Coarse-Grained Model for the Functional State of the Nuclear Pore Complex
Figure 9
The histograms on left show the radial probability distribution of the cargo-complex versus the channel radius (the bin size is 1 nm).
The cargo diameter is indicated inside the plot area. Each diagram is averaged over 50 independent simulations. Histograms are fit with Gaussian distributions (red dash line). The peak ± SD is recorded on top of histograms for each cargo size. Color bars on the right side show the radial probability distribution inside the central channel geometry. The more reddish, the higher the probability density. As it can be seen both in histograms and color bars, the large cargo is more likely to attach to the wall and less likely to disperse in the channel as opposed to the smaller cargo. This is partly due to its larger surface area and smaller diffusion coefficient, which make it less mobile compared the smaller cargo.