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Combinations of Protein-Chemical Complex Structures Reveal New Targets for Established Drugs

Figure 4

Extrapolation of growth rates for complexes of human proteins with drugs, resolved using experimental methods (red) and amenable to prediction using our method (green) over time.

The sum of the two curves is shown in blue. The total number of existing drug-target complexes is shown in gray and estimated given the average number of targets per drug to be between 3 and 15, the number of targets to be fixed at 5000 and the number of drugs to be increasing linearly at the rate of between 10 and 50 per year (see text for details).

Figure 4