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Autonomous Targeting of Infectious Superspreaders Using Engineered Transmissible Therapies

Figure 6

TIPs evolve toward robust reduction in disease prevalence.

(a) Predicted HIV viral set point as a function of TIP encoded inhibition of HIV (parameter D from the intracellular model, see Text S1) where negative inhibition values indicate TIP evolving to upregulate HIV gene expression within a single cell. Inset: Increasing upregulation generates higher TIP viral loads at the individual patient level and leads to lower HIV viral loads. (b) HIV/AIDS disease prevalence as a function of TIP encoded inhibition of HIV where negative inhibition values indicate TIP evolving to upregulate HIV expression. Increasing upregulation generates lower HIV/AIDS prevalence at the population level. Inset: TIP prevalence is reduced as upregulation increases, potentially creating an evolutionary trap for the TIP.

Figure 6

doi: https://doi.org/10.1371/journal.pcbi.1002015.g006