Autonomous Targeting of Infectious Superspreaders Using Engineered Transmissible Therapies
Projected 50-year impact of TIP intervention on (a) HIV/AIDS disease prevalence and (b) number of deaths averted in the presence and absence of behavioral disinhibition (dashed and solid lines, respectively). TIP interventions (light and dark blue) are compared to vaccination (light and dark grey), ART (black), and the scenario of no intervention (dashed red line). Disinhibition is modeled as in  by assuming that individual person-to-person contact rates increase upon introduction of vaccine or TIP intervention. Projected 50-year impact of ART in presence of TIP intervention (light and dark purple) on (c) HIV/AIDS disease prevalence and (d) number of deaths averted compared to projected 50-year impact of ART alone (black, 75% ART coverage without TIP intervention). Dashed and solid lines are the presence and absence of behavioral disinhibition, respectively. ART and vaccine campaigns are modeled as in Figure 2.