Impact of Fast Sodium Channel Inactivation on Spike Threshold Dynamics and Synaptic Integration
An iLIF model was stimulated by fluctuating inputs with different means and standard deviations and the threshold distribution was measured. A, Average threshold (color-coded) as a function of the mean (<V>) and standard deviation (σV) of the membrane potential. The average threshold depends primarily on the average membrane potential. White areas correspond to parameter values that were not tested (top) or that elicited no spike (bottom). B, Standard deviation of the threshold as a function of membrane potential statistics. Threshold variability depends on both the average and the standard deviation of the membrane potential.