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Impact of Fast Sodium Channel Inactivation on Spike Threshold Dynamics and Synaptic Integration

Figure 4

Predicted relationship between mean membrane potential and mean threshold.

We simulated the iLIF model (see Methods) with a fluctuating input current. The standard deviation was fixed while the mean current was varied between trials. The mean spike threshold () is plotted as a function of the mean membrane potential (). The slope of the curve is larger above half-inactivation voltage Vi (0.64 from linear regression, red line) than below (0.23).

Figure 4