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Vulnerabilities in the Tau Network and the Role of Ultrasensitive Points in Tau Pathophysiology

Figure 6

Time-dependent response to perturbations.

A 5-fold increase in the parameter associated with the binding of normally phosphorylated, 3R tau to microtubules was applied and the response of unphosphorylated, microtubule bound 4R tau was monitored with respect to the basal concentration of this species. The perturbation results in a decrease in concentration with respect to basal in the healthy neuron, while in the aggregation-prone neuron, an increase in protein concentration is observed.

Figure 6