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Vulnerabilities in the Tau Network and the Role of Ultrasensitive Points in Tau Pathophysiology

Figure 3

Ultrasensitivity in the populations.

The cube root of the median sensitivity coefficients for each state across all parameters is shown with coefficients exceeding a 10-fold change in a state compared to the parameter perturbation highlighted. The ultrasensitive coefficients, which are denoted by the red and blue circled markers in the healthy and aggregation-prone populations, represent multiple individuals.

Figure 3