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Vulnerabilities in the Tau Network and the Role of Ultrasensitive Points in Tau Pathophysiology

Figure 2

Relative, steady-state sensitivity for the healthy population of in silico neuron models.

Median sensitivity coefficient at steady-state is shown for pairs of states (proteins) and parameters (rate constants). States and parameters associated with the chaperone and degradation are not shown, as this network is not engaged when the model is behaving in a manner consistent with a healthy neuron.

Figure 2

doi: https://doi.org/10.1371/journal.pcbi.1000997.g002