Drug Off-Target Effects Predicted Using Structural Analysis in the Context of a Metabolic Network Model
Figure 5
CETP inhibitor renal response phenotypes.
Elements of the color matrix represent the percent of the maximum normal, untreated renal objective flux achievable by the CETP-inhibitor-treated normal kidney model. The x-axis corresponds to individual renal objective functions, and the y-axis corresponds to the predicted drug off-targets. Metabolite abbreviations are defined in Table 1. Only the subset of renal objective functions for which a drug response phenotype was predicted is displayed.