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Drug Off-Target Effects Predicted Using Structural Analysis in the Context of a Metabolic Network Model

Figure 5

CETP inhibitor renal response phenotypes.

Elements of the color matrix represent the percent of the maximum normal, untreated renal objective flux achievable by the CETP-inhibitor-treated normal kidney model. The x-axis corresponds to individual renal objective functions, and the y-axis corresponds to the predicted drug off-targets. Metabolite abbreviations are defined in Table 1. Only the subset of renal objective functions for which a drug response phenotype was predicted is displayed.

Figure 5

doi: https://doi.org/10.1371/journal.pcbi.1000938.g005