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Drug Off-Target Effects Predicted Using Structural Analysis in the Context of a Metabolic Network Model

Figure 3

Reduced kidney model subsystem distribution.

The distribution of metabolic reactions predicted to be active in the reduced kidney model with respect to broad metabolic subsystem categories is shown. The distribution excludes objective function, exchange, and demand reactions used to perform simulations in the model.

Figure 3

doi: https://doi.org/10.1371/journal.pcbi.1000938.g003