Drug Off-Target Effects Predicted Using Structural Analysis in the Context of a Metabolic Network Model
The pie chart at bottom represents the Recon1 gene activity predictions resulting from deriving the kidney model. Genes predicted inactive are those genes with no associated active reaction fluxes in the kidney model. Genes for which no activity prediction was made are those associated with active reaction fluxes in the kidney model but either are not represented in the gene expression data or were not determined as the gene whose expression level is most limiting for any associated reaction through evaluation of GPR Boolean rules with respect to gene expression data. The slice at top represents genes predicted active in the kidney model.