Role of Hsp70 ATPase Domain Intrinsic Dynamics and Sequence Evolution in Enabling its Functional Interactions with NEFs
(a) Ribbon diagram colored by the ET rank of residues, from red (most conserved) to blue (most variable). (b) The average mobility of residues corresponding to different ET ranks. The mobilities are evaluated using Equation 1. The bars display the standard error for each ET rank. Best fitting second order polynomial (red curve) is shown to guide the eye (correlation coefficient of 0.92). See also SM Figure S7 panel b for a similar plot, based on ConSurf score (instead of ET rank).