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One Rule to Grow Them All: A General Theory of Neuronal Branching and Its Practical Application

Figure 5

A general strategy for generating synthetic morphologies: Cortical pyramidal cells.

(A) After rotating rat somatosensory cortex layer 2/3, 4 and 5 pyramidal cells to overlap, the limits of their individual regions were extracted: black shaded boxes show the mean limits in XY for the apical region; the black empty boxes delineate one standard deviation away from the mean. Corresponding red boxes duplicate this procedure for the basal dendrites. Cells are then scaled region-by-region to the mean limits of each region. Overlay colours describe local density (colormap see Figure 2D) of lumped topological points of scaled trees. (B) Same procedure for three groups of cortical pyramidal cells during development. (C) Construction stages of a sample layer 5 pyramidal cell according to spanning fields described in A. First the apical tuft is constructed, then oblique dendrites and finally the basal dendrite. Spatial jitter and diameter values are added subsequently.

Figure 5

doi: https://doi.org/10.1371/journal.pcbi.1000877.g005