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A Comprehensive, Quantitative, and Genome-Wide Model of Translation

Figure 4

Correlation of mRNA and protein expression levels.

The plot shows the correlation between mRNA abundance (parameter ) and the number of protein molecules produced from a given gene (parameter ). We performed linear regression through the origin on log transformed data. Adjusted value calculated over the entire dataset (4192 genes of known ) was 0.59. This means that over 40% (in log space) of the variation in protein abundance cannot be explained by variation in mRNA abundance, suggesting some additional, posttranscriptional mechanisms of gene expression regulation.

Figure 4