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A Threshold Equation for Action Potential Initiation

Figure 3

Influence of Na activation characteristics on spike threshold.

A, Excitability curve of the model for different values of the ratio gNa/gL (maximum Na conductance over leak conductance), discarding inactivation (h = 1) and other ionic conductances. The resulting threshold is shown with a red dot. B, Excitability curve for different values of half-activation voltage Va. C, Excitability curve for different values of Boltzmann factor ka. D, Threshold as a function of the ratio gNa/gL for the 9 types of voltage-gated sodium channels [52] with characteristics reported in (Angelino and Brenner, 2007 [51]). For each channel type, the mean threshold obtained across the dataset is plotted. Nav1.[1], [2], [3], [6] are expressed in the central nervous system, Nav1.[4], [5] are expressed in cardiac and muscle cells and Nav1.[7], [8], [9] are expressed in the peripheral nervous system. Nav1.6 is expressed at the action potential initiation site [53][55].

Figure 3