Novel Peptide-Mediated Interactions Derived from High-Resolution 3-Dimensional Structures
Figure 5
DMIs significantly enriched in the interactomes.
Significantly enriched motifs were found for 46 distinct domains (shown in gray; PCNA_N and PCNA_C are shown in the same structure). Binding peptides are given in a rainbow colour scheme, with the SVM-accepted part in sticks representation and the consensus motif in surface representation. In most cases, differences between the interaction types for a given domain are subtle, thus only one is shown in this representative figure. However, for domains that form repeats to bind peptides (Arm, BRCT (cf. Fig. 4 and main text), TPR_1, TRF, WD40), we have visualized all domains required to bind one peptide; these usually employ different interaction types. Blue domain names indicate those that were described in the ELM training dataset [11], violet names mark additions to ELM since 2007 [32], which were not in our training set, and green names indicate DMIs that are described on the Pawson lab web site [60] but not in ELM.