Simulating Microdosimetry in a Virtual Hepatic Lobule
Figure 3
Five different lobule morphologies were examined.
They are: a) one portal triad, no branching or noise, b) six portal triads with noise and additional sinusoids, c) six portal triads, 10% chance of branching, d) three portal triads with 10% branching, and e) six portal triads with 5% chance of branching. Though the overall layout (middle column) can be compared qualitatively with physiology, we evaluate these geometries by comparing the flow (left-hand column) predicted for a rat with in vivo measurements of flow in rat sinusoids (Komatsu et al. (1990) [31]). We also compare (right-hand column) the radial dependence of concentration at tmax with the prediction for a well-mixed compartment with equivalent metabolic clearance (heavy dashed line). Comparison of profiles b-e with profile a provides an approximate comparison to a parallel tubes prediction. The solid line indicates the mean for multiple lobules and sinusoids, while the shading indicates the 95% quantile (variability).