A Dynamic Model of Interactions of Ca2+, Calmodulin, and Catalytic Subunits of Ca2+/Calmodulin-Dependent Protein Kinase II
The initial conditions for the simulation were [CaM] = 30 µM, [mCaMKII] = 80 µM, and [Ca2+] = 10 µM. A) Time course of formation of species of free CaM. B) Time course of formation of species of CaM bound to CaMKII (K•CaM). C) Time course of formation of species of CaM bound to phosphorylated CaMKII (pK•CaM). The color code for Ca2+ occupation of sites on CaM is indicated on the lower left. *color code applies to all forms of CaM with the indicated bound Ca2+. Note differences in scale for panels A), B) and C).