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A Dynamic Model of Interactions of Ca2+, Calmodulin, and Catalytic Subunits of Ca2+/Calmodulin-Dependent Protein Kinase II

Figure 6

Model of autophosphorylation of one mCaMKII by another.

Autophosphorylation requires that CaM be bound to both the subunit acting as “enzyme” and the subunit acting as “substrate”. A range of association rate constants for the subunit complex (Table S1) were calculated based upon estimated affinity constants from experimental studies as described in Text S1. Phosphorylated K•CaMnNcC species are denoted pK•CaMnNcC.

Figure 6

doi: https://doi.org/10.1371/journal.pcbi.1000675.g006