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A Dynamic Model of Interactions of Ca2+, Calmodulin, and Catalytic Subunits of Ca2+/Calmodulin-Dependent Protein Kinase II

Figure 5

Model 2: coarse-grained model of binding among Ca2+, CaM and CaMKII.

The reaction network includes only pairs of Ca2+ ions, assuming highly cooperative binding at each CaM terminus. Rate constants were derived from those for Model 1 as described in Text S1.

Figure 5

doi: https://doi.org/10.1371/journal.pcbi.1000675.g005