Integrin Clustering Is Driven by Mechanical Resistance from the Glycocalyx and the Substrate
Figure 7
Integrin-ligand affinity, glycocalyx thickness, and bond length control integrin bond formation and clustering.
The maximal Ripley clustering statistic (A) and equilibrium integrin bond fraction (B) resulting from simulations on rigid substrates with various combinations of effective glycocalyx thickness (lg−lb) and integrin-ligand affinity (See Table 1 for parameters not depicted).