Global Motions of the Nuclear Pore Complex: Insights from Elastic Network Models
(A) Three views are shown for the second mode of a toroid with axially varying mass density. In each view, the z-axis is shown (by the dot or arrow). The uneven mass distribution causes increased mobility on the lighter side of the toroid (compare to Figure 2B). (B) The fraction change in mobility, ΔB/B, from the uniform-density toroid is plotted against axial coordinate for three toroid models with non-uniform mass distributions: mass distributions linearly dependent on radial coordinate (red squares), distance from minor axis (black circles), and axial coordinate (blue triangles). The solid lines and filled symbols refer to the first mode, which is only slightly altered in the first two cases, as indicated by all points falling close to zero on the ordinate. When the mass is distributed such that the cytoplasmic (z>0) side is more massive than the nuclear (z<0) side, there is an increase in mobility in the cytoplasmic side and a decrease in mobility in the nuclear side relative to the first mode. The opposite effect is observed for the second mode, shown in dashed lines.