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Statistical Methods for Detecting Differentially Abundant Features in Clinical Metagenomic Samples

Figure 2

Detecting differential abundance for sparse features.

A 2×2 contingency table is used in Fisher's exact test for differential abundance between rare features. f11 is the number of observations of feature i in all individuals from treatment 1. f21 is the number of observations that are not feature i in all individuals from treatment 1. f12 and f22 are similarly defined for treatment 2.

Figure 2

doi: https://doi.org/10.1371/journal.pcbi.1000352.g002