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Phylogenetic and Functional Assessment of Orthologs Inference Projects and Methods

Figure 4

Results of functional based tests.

Results of functional conservation tests for GO similarity, EC number expression correlation and gene neighborhood conservation. In the pairwise project comparisons (left) the relative difference of functional similarity between OMA and its counter project versus the relative difference of the number of predicted orthologs are shown. In the comparison on the intersection set (right), the mean functional similarity versus the number of predicted orthologs on the common set of sequences are shown. The vertical error bars in all the results state the 95% confidence interval of the means. The “better arrow” indicates the direction towards higher specificity and sensitivity. Projects lying in the gray area are dominated by “OMA Pairwise” in the pairwise comparison (left) and by at least one other project in the intersection comparison (right).

Figure 4

doi: https://doi.org/10.1371/journal.pcbi.1000262.g004