A Model of Brain Circulation and Metabolism: NIRS Signal Changes during Physiological Challenges
The CuA centre is reduced by some reducing substrate, termed R. It in turn passes its electrons on to a terminal substrate, cyta3. Finally cyta3 is oxidised by oxygen. All processes can in general produce proton motive force Δp, by pumping protons out of the mitochondrial matrix. As a result, they are also inhibited by Δp. The rates of the three processes – initial reduction of CuA, electron transfer to cyta3 and final oxidation of cyta3, are termed f1, f2 and f3, respectively.