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An End to Endless Forms: Epistasis, Phenotype Distribution Bias, and Nonuniform Evolution

Figure 1

An illustration of the developmental model.

The r transcription factors bind to the promoters of k structural genes with affinities given by Dij. If the net activation to a promoter exceeds a threshold value (illustrated as a step function) the gene is expressed. The phenotype is described by the distribution of gene expression. This regulatory architecture corresponds to the single layered plan - See also our analysis of a generalized, multilayered, model.

Figure 1

doi: https://doi.org/10.1371/journal.pcbi.1000202.g001