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ChromaSig: A Probabilistic Approach to Finding Common Chromatin Signatures in the Human Genome

Figure 2

ChromaSig clusters recovered from 9 chromatin marks mapped by ChIP–chip in HeLa cells on ENCODE arrays.

Heatmaps (top) and average histone modification profiles (bottom) for each cluster output by ChromaSig. Each horizontal line in the heatmap represents chromatin marks for a single locus. The window size for each mark is 10-kb. Nine histone marks (H4ac, H3ac, H3K9ac, H3K18ac, H3K27ac, H3K4me1, H3K4me2, H3K4me3, and H3) used by ChromaSig and three independent functional marks (RNAPII, TAF250, p300) are presented. To organize these clusters visually, we use hierarchical clustering with a Euclidean distance metric (left).

Figure 2