Gene-Boosted Assembly of a Novel Bacterial Genome from Very Short Reads
The target genome is shown in the center, aligned to two related genomes, A and B. The DNA sequence of the target diverges from the reference genomes in distinct loci, labeled X, Y, and Z. The comparative assembly based on genome A contains a gap corresponding to region Y, while the assembly based on genome B contains two gaps, corresponding to X and Z. The merged assembly will cover all of the target genome with no gaps.