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Modeling Recursive RNA Interference

Figure 7

Effect of RdRP-mediated amplification.

Each graph shows restoration versus time for numerical simulations of recursive RNAi experiments targeting Dicer. (A) gamma = 1. (B) gamma = 200. Within each graph, results for different values of the amplification efficacy parameter theta are given. Theta is proportional to the number of secondary siRNA molecules produced by RdRP for each targeted mRNA molecule. Modification of model equations to incorporate RdRP activity is described in Materials and Methods.

Figure 7