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Modeling Recursive RNA Interference

Figure 2

Phase plane diagram of recursive RNAi of Dicer.

Phase plane diagram of Dicer RNAi showing the nullclines for which the rate of change of either the siRNA (in blue) or Dicer protein (in red) equals zero. The two curves only intersect for one set of values, indicating a unique steady-state solution. The transient solution starting from an initial condition of normal dicer level and zero Dicer-directed siRNA is plotted in green, obtained by numerical integration. This simulation was conducted with an RNAi efficacy parameter gamma equal to 1.

Figure 2