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Regulatory Control and the Costs and Benefits of Biochemical Noise

Figure 4

The Optimal Design of the lac Regulatory Network Is Determined by the lac Repressor Copy Number and the Repressor–Lactose Binding Constant.

Contour plot of the growth rate as a function of the repressor copy number X and repressor-lactose binding constant KD. The weighting of the lactose levels is nonuniform. Lower binding constants allow for higher optimal growth rates at lower optimal expression levels for the repressor.

Figure 4

doi: https://doi.org/10.1371/journal.pcbi.1000125.g004