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Regulatory Control and the Costs and Benefits of Biochemical Noise

Figure 3

Different Regulatory Networks Can Yield the Same Optimal Enzyme Expression Level as a Function of Inducer Concentration.

This is illustrated for two regulatory networks of the lac system, which differ in the dissociation constants of lactose-repressor binding and repressor-operator binding. Panels (A) and (B) show the response functions at two different stages of the lac regulatory network, while panel (C) shows the resulting optimal enzyme expression level as a function of lactose concentration. (A) The fraction of repressor that is not bound by lactose, Xfree/X, as a function of lactose concentration for two different lactose-repressor binding constants. (B) The corresponding response curves of the enzyme expression level as a function of the fraction of free repressor. The total expression level of repressor is chosen to correspond to the optimal growth rate (see Figure 2). (C) The resulting optimal enzyme expression level as a function of the lactose concentration, as predicted by Equation 20 [12].

Figure 3

doi: https://doi.org/10.1371/journal.pcbi.1000125.g003