Emergent Synchronous Bursting of Oxytocin Neuronal Network
(A) Schematic illustrating the organization of a single model neuron: it receives random excitatory and inhibitory synaptic inputs, and its excitability is modelled as a dynamically changing spike threshold that is influenced by a post-spike HAP (parameter THAP), and a slower AHP (TAHP). Each neuron interacts with neighbouring oxytocin neurons by two dendrites that project to bundles (yellow), and its excitability is increased when oxytocin is released in the vicinity of these dendrites (TOT). Activity-dependent production of endocannabinoids (EC) feeds back to reduce synaptic input rates. (B) This analyses the behavior of one model cell during a burst in detail. The upper two raster traces show the times of occurrence of all oxytocin release events in the two dendritic bundles to which the cell is connected. Below this is the soma activity: the black line (V) shows the impact of excitatory and inhibitory inputs, and the blue line shows the dynamic spike threshold, showing the effects of post-spike activity changes and the effects of oxytocin. The bottom three traces show THAP , TAHP, and TOT.