Context-Specific Metabolic Networks Are Consistent with Experiments
Figure 11
A comparison of skeletal muscle models, using only reactions that have data for both gene chips used.
This figure is the same as Figure 10, but the distances that are graphically represented are computed using only reactions that have data on both types of gene chips. The 5% of reactions that are represented on the U133+ 2.0 chip but not the U133A chip are not used for comparison. Here we no longer see any bias based on chip type, but rather we see that the FO datasets appear to be similar to both GI and GB data sets, instead of just the GI data sets. The chip type does not appear to affect the distances as much as the different experiments do. The chip type does appear to affect the reactions that the algorithm defines as active versus inactive, as seen in the differences between Figures 10 and 11.