Performance and Scalability of Discriminative Metrics for Comparative Gene Identification in 12 Drosophila Genomes
(A) Phylogenetic tree and estimated neutral branch lengths for the species. Tree topology follows the accepted phylogeny of these species ,. Neutral substitution rates estimated from 12,861 4-fold degenerate sites in syntenic one-to-one orthologs (see Methods). (B) Pairwise distance of each of the 11 other Drosophila species from D. melanogaster, as compared to similarly estimated distances for vertebrates. (C) Total independent branch length provided by several subsets of the Drosophila species used to benchmark multi-species methods.