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Functional Maps of Protein Complexes from Quantitative Genetic Interaction Data

Figure 5

Pathway models identify novel functional associations among cellular machinery.

Each panel represents complexes and between-complex links taken from Figure 2. Physical interactions with PE>1 are shown and strong genetic interactions (|S|>2.5) are shown with increased thicknesses corresponding to stronger genetic interactions. (A) Histone acetyltransferase complex RTT109 – VPS75 showing strong alleviating interactions with the Elongator transcription elongation factor complex. (B) Between-complex model highlighting alleviating interactions between the LRP1 – RRP6 nuclear exosome complex and an mRNA degradation complex. (C) Complexes associated with the RAD6-C histone ubiquitination complex (BRE1/LGE1).

Figure 5