Functional Maps of Protein Complexes from Quantitative Genetic Interaction Data
The percentage of complexes that contain at least one essential gene is shown, for various groups of complexes defined within small-scale complexes in MIPS (left three bars) or complexes identified in this study (right three bars). In MIPS, approximately 80% of “aggravating” complexes (see text) contain an essential gene, versus 20% for “alleviating” complexes. The trend is similar for the complexes reported in this study, with 55% versus 22% of aggravating versus alleviating complexes containing an essential gene. The list of all essential genes was taken from (http://www-sequence.stanford.edu/group/yeast_deletion_project/deletions3.html).