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Functional Maps of Protein Complexes from Quantitative Genetic Interaction Data

Figure 4

Aggravating complexes are more likely to contain essential genes.

The percentage of complexes that contain at least one essential gene is shown, for various groups of complexes defined within small-scale complexes in MIPS (left three bars) or complexes identified in this study (right three bars). In MIPS, approximately 80% of “aggravating” complexes (see text) contain an essential gene, versus 20% for “alleviating” complexes. The trend is similar for the complexes reported in this study, with 55% versus 22% of aggravating versus alleviating complexes containing an essential gene. The list of all essential genes was taken from (

Figure 4