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Sequence Similarity Network Reveals Common Ancestry of Multidomain Proteins

Figure 2

Domain models of a pair of multidomain homologs and a pair of sequences with a domain-only match.

(A) Domain architectures of the multidomain homologs PDGFRB and PRKG1B. These sequences share a Pkinase domain, but have different auxiliary domains. (B) Domain architectures of PDGFRB and NCAM2, which have significant sequence similarity due to shared Ig domains, but do not share common ancestry.

Figure 2

doi: https://doi.org/10.1371/journal.pcbi.1000063.g002