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Prediction of Human Disease Genes by Human-Mouse Conserved Coexpression Analysis

Figure 4

Example of identification of candidate disease genes.

Identification of KCNIP4 (green) in the genomic locus 4p15 (containing 86 genes; orange), associated with partial epilepsy with pericentral spikes (OMIM ID 607221). KCNIP4 was found in a disease-related cluster composed of LOC399947 and its nearest neighbors (red and purple spheres, respectively) that contains 5 other genes known to be involved in similar phenotypes (yellow spheres). A second candidate for this disease was found in another disease-associated cluster (not shown; see Table 2).

Figure 4

doi: https://doi.org/10.1371/journal.pcbi.1000043.g004