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Prediction of Human Disease Genes by Human-Mouse Conserved Coexpression Analysis

Figure 2

Comparison of the Affy and Stanford networks with functional, physical interaction, and disease-related information.

(A) Prevalence of functionally related coexpression clusters (see Materials and Methods). (B) Number of edges of the CCN joining proteins previously shown to physically interact by different techniques, as deduced by the HPRD database. (C) Number of edges of the indicated networks connecting genes involved in Mendelian phenotypes sharing a MimMiner score of 0.4 or higher. In each case, the results for the actual CCNs are compared to the results averaged on 100 randomized CCNs, with error bars representing the standard deviation of the latter.

Figure 2

doi: https://doi.org/10.1371/journal.pcbi.1000043.g002