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Prediction of Human Disease Genes by Human-Mouse Conserved Coexpression Analysis

Figure 1

Identification of candidate disease genes by means of conserved co-expression clusters.

A locus with positional candidates (green bar) associated with a disease of unknown molecular basis (yellow) is screened for one or more candidate genes (green sphere) that appear in a conserved coexpression cluster (purple spheres) together with at least two other genes known to be involved in similar phenotypes (yellow spheres), as defined by the MimMiner similarity score.

Figure 1

doi: https://doi.org/10.1371/journal.pcbi.1000043.g001