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Mutations of Different Molecular Origins Exhibit Contrasting Patterns of Regional Substitution Rate Variation

Figure 1

Histogram of the rate of CG->TA substitutions in non-coding regions.

The rate of CG->TA transitions in CpG sites (A), and GpC sites (B) in 50 kb segments of non-coding regions having at least 10,000 aligned sites. Variation of CpG substitution rate among non-coding regions is significantly greater than that expected under a uniform substitution rate model. A similar result was obtained for GpC sites (see text).

Figure 1

doi: https://doi.org/10.1371/journal.pcbi.1000015.g001