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Open Access
Peer-reviewed
Research Article
MicroRNAs Form Triplexes with Double Stranded DNA at Sequence-Specific Binding Sites; a Eukaryotic Mechanism via which microRNAs Could Directly Alter Gene Expression
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Steven W. Paugh ,
Contributed equally to this work with: Steven W. Paugh, David R. Coss, Ju Bao, Lucas T. Laudermilk
Affiliations Hematological Malignancies Program, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America, Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
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David R. Coss ,
Contributed equally to this work with: Steven W. Paugh, David R. Coss, Ju Bao, Lucas T. Laudermilk
Affiliation High Performance Computing Facility, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
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Ju Bao ,
Contributed equally to this work with: Steven W. Paugh, David R. Coss, Ju Bao, Lucas T. Laudermilk
Affiliations Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America, Department of Structural Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
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Lucas T. Laudermilk ,
Contributed equally to this work with: Steven W. Paugh, David R. Coss, Ju Bao, Lucas T. Laudermilk
Affiliations Hematological Malignancies Program, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America, Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
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Christy R. Grace,
Affiliation Department of Structural Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
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Antonio M. Ferreira,
Affiliation High Performance Computing Facility, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
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M. Brett Waddell,
Affiliation Molecular Interaction Analysis Laboratory, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
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Granger Ridout,
Affiliation Functional Genomics Laboratory, Hartwell Center for Bioinformatics & Biotechnology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
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Deanna Naeve,
Affiliation Functional Genomics Laboratory, Hartwell Center for Bioinformatics & Biotechnology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
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Michael Leuze,
Affiliation Computer Science and Mathematics Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, United States of America
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Philip F. LoCascio,
Affiliation Doctoral Training Centre, University of Oxford, Oxford, United Kingdom
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John C. Panetta,
Affiliation Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
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Mark R. Wilkinson,
Affiliations Hematological Malignancies Program, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America, Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
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Ching-Hon Pui,
Affiliations Hematological Malignancies Program, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America, Department of Oncology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
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Clayton W. Naeve,
Affiliation Department of Information Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
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Edward C. Uberbacher,
Affiliation Computer Science and Mathematics Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, United States of America
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Erik J. Bonten,
Affiliations Hematological Malignancies Program, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America, Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
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William E. Evans
* E-mail: william.evans@stjude.org
Affiliations Hematological Malignancies Program, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America, Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
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MicroRNAs Form Triplexes with Double Stranded DNA at Sequence-Specific Binding Sites; a Eukaryotic Mechanism via which microRNAs Could Directly Alter Gene Expression
- Steven W. Paugh,
- David R. Coss,
- Ju Bao,
- Lucas T. Laudermilk,
- Christy R. Grace,
- Antonio M. Ferreira,
- M. Brett Waddell,
- Granger Ridout,
- Deanna Naeve,
- Michael Leuze
- Published: February 4, 2016
- https://doi.org/10.1371/journal.pcbi.1004744