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One spiking model reproducing varying activity

Posted by SOVF on 20 Sep 2010 at 05:44 GMT

These systematically varying, persistent temporal firing profiles are similar to those observed experimentally in vivo in frontal cortex during the delay period of the WM task [1], [3], [38], [39], but no previous spiking model of WM could reproduce them.

The authors claim that no spiking model could reproduce the systematically varying, persistent firing profiles as observed in frontal cortex. It seems they were unaware of this paper:

Verduzco-Flores S, Bodner M, Ermentrout B, Fuster JM, Zhou Y (2009) Working Memory Cells' Behavior May Be Explained by Cross-Regional Networks with Synaptic Facilitation. PLoS ONE 4(8): e6399. doi:10.1371/journal.pone.0006399


The cited paper reproduces the delay period firing patterns reported in the following, rather extensive study:

Shafi M, Zhou Y, Quintana J, Chow C, Fuster J, Bodner M (2007) Variability in neuronal activity in primate cortex during working memory tasks. Neuroscience 146: 1082–1106.

No competing interests declared.